MTHFR and type 2 diabetes mellitus: We found significant association between MTHFR C677T genotype and T2DM in Asian populations, under each genetic models homozygous (OR = 1.78, 95% CI = 1.48–2.15), heterozygous (OR = 1.51, 95% CI = 1.33–1.70), recessive (OR = 1.43, 95% CI = 1.23–1.67), dominant (OR = 1.60, 95% CI = 1.40–1.82), and allele (OR = 1.44, 95% CI = 1.29–1.59).