These results demonstrated from functional analysis promoted apolipoprotein A‐I, apolipoprotein A‐II, hemoglobin subunit alpha, and haptoglobin mediated with TLR, TNF α, IL‐4, IL‐6 and IFN γ during apoptosis mechanism, could be potential avenues for prevention, treatment and monitoring in osteopenia. The gene discussed is IL4; the disease is Osteopenia.