TGM5 and peeling skin syndrome 1: Acral peeling skin syndrome (APSS; PSS2; Mendelian Inheritance in Man [MIM] #609796) is considered a localized variant of PSS and is caused by mutations in TGM5 encoding transglutaminase 5 (TGM5).2 The generalized form is subclassified into non‐inflammatory (type A) (PSS3; MIM #616265) and inflammatory (type B) forms (PSD; PSS1; MIM #270300).3 PSS type A is linked to mutations in CHST8. 4 Recently, mutations in FLG2 were described in patients with generalized skin peeling.5, 6