FAS and neoplasm: From 2004 to 2010, 37% and 52% of white patients presented with loco regional and distant disease versus 34% and 57% of AA patients.16 Differences in tumor biology may contribute to a more advanced stage at diagnosis for AAs.17 Clinicopathologic analysis of AA patients compared to white patients is notable for a higher presence of K-mutations at codon 12 and less frequent FAS expression, a finding described in other malignancies.18 Further study is needed to ascertain the role, if any, of these biological factors.