To decide whether or not epigenetic changes may additionally play a position in the improvement of adult diabetes following Intrauterine growth regulations (IUGR), we used a rodent model of Intrauterine growth regulations (IUGR) that expresses decrease levels of Pdx1, a pancreatic and duodenal home box 1 transcription factor fundamental for β cell characteristic and development, which develops diabetes in adulthood [22]. The gene discussed is PDX1; the disease is diabetes mellitus.