TP53 and cancer: Last, the observed increases in fluorescence were found to be Aβ42 specific, as the isolated pSICLOPPS-NuX1X2X3X4X5X6 vectors did not enhance the levels of cellular green fluorescence when the sequence of Aβ42 was replaced in the same vector with that of the DNA-binding (core) domain of human p53 containing a tyrosine to cysteine substitution at position 220 [p53C (Y220C)], a protein whose misfolding and aggregation is associated with certain forms of cancer (fig.