We are currently using this system to screen molecular libraries with expanded diversities, such as the ones described here, and have identified candidate macrocyclic rescuers of the misfolding and aggregation of variants of human Cu/Zn superoxide dismutase and p53, as well as of huntingtin, whose misfolding and aggregation are associated with amyotrophic lateral sclerosis, cancer, and Huntington’s disease, respectively (1). The gene discussed is HTT; the disease is cancer.