Interestingly, we found that the effect of EA on the thyroid hormone signaling pathway is very prominent in T2DM, with both upregulated genes (MED13, MED13L, NCOA2, PIK3CB, and SLC16A10) and downregulated genes (MED12L, PLCG2, PRKCA, and TSC2) being observed. Here, TSC2 is linked to type 2 diabetes mellitus.