HSPG2 and neoplasm: So, MMP-9 takes part in angiogenic switch since it results in increasing the critical factors required in this procedure, for example, the vascular endothelial growth factor (VEGF), the most potent mediator of tumor vasculature and basic fibroblast growth factor (bFGF), by degrading the extracellular segments, for example, collagen types IV, XVIII, and perlecan, respectively [30, 33].