In another two investigations, nuclear factor erythroid-2-related factor 2 (Nrf2), a nuclear transcription factor with neuroprotective effects against central nervous system disease, was reported to be involved in curcumin-induced neuroprotection against hypoxic-ischemic brain injury in neonatal rats and against OGD/R injury in primary cultured cortical neurons [29, 30]. The gene discussed is NFE2L2; the disease is central nervous system disorder.