The therapeutic value of pharmacological chaperones (small molecules specifically stabilising a misfolded glycoprotein as it traverses the ER) is already well established in a number of congenital glycoprotein misfolding endocrine and metabolic disorders [12], further supporting the idea that therapeutic modulation of ER glycoprotein folding and degradation systems could also be successfully applied to cancer treatment, at least in cases where ERQC-assisted glycoprotein folding and ERAD play a major role. Here, ART4 is linked to metabolic disease.