Figure 2 shows the TTP curve and OS curve. The median TTP in patients with acral melanomas, mucosal melanomas, and CSD/non-CSD melanomas was 5.3 months (95% CI: 2.4–8.2), 6.0 months (95% CI: 2.9–9.1), and 4 months (95% CI: 1.9–6.1), respectively. Detailed median TTPs according to clinical features are listed in . Univariate analysis based on clinical features revealed that ECOG scores, liver metastasis, and elevated LDH and CRP levels were factors affecting TTP; multivariate analysis indicated that only the ECOG score was an independent predictor for shorter TTP (P=0.032). The gene discussed is CRP; the disease is acral lentiginous melanoma.