IL6 and malignant colon neoplasm: It has been suggested that most important role of AvrA in colon cancer may be related to inflammatory and immune response dysregulation, through several mechanisms such as: inhibition of NF-ΚB signaling pathway [121], inhibition of IL-12, INF-γ and TNF-α secretion [122], inhibition of IL-6 transcription and increasing on IL-10 transcription [123].