CTLA4 and colorectal carcinoma: In particular, the recent FDA approval of cytotoxic antibodies expressed on regulatory lymphocytes (Tregs) such as anti-CTLA-4 ipilimumab and anti-PD-L1 atezolizumab, in the treatment of CRC inspired the use of these new tools in nanomedicine, combining treatments able to induce immunogenic cell death (ICD) and with their Treg suppressive action.