CD274 and gastric neoplasm: It has been demonstrated that EBV+ gastric tumors have very distinctive molecular features, including amplification (also overexpression) of PD-L1 and PD-L2, conspicuous intratumoral or peritumoral immune cell infiltration, especially of CD8+ T cells, and IFN-γ-driven gene expression profile (GEP) (Figure 1(d)) [14, 103, 104].