Furthermore, the hyperglycemic stress response in patients undergoing major abdominal surgery under isoflurane general anesthesia could be related to an increase in endogenous glucose production accompanied by a decrease in glucose utilization [9, 20] Tanaka et al. [21]showed that there was glucose intolerance and impairment of insulin secretion and glucose utilization during sevoflurane and isoflurane anesthesia in a dose-independent manner. The gene discussed is INS; the disease is Glucose intolerance.