MCOLN1 and nasopharyngeal carcinoma: In Niemann–Pick Disease Type C (NPC), another LSD, associated with defected NPC1 or NPC2 proteins and the consequent lysosomal accumulation of lipids such as cholesterol, TRPML1 channel activity is reduced by 70% [54] while ROS level is elevated when compared with WT fibroblasts [27,55].