An association between CD133 and OXPHOS was reported by Denise et al. [40] who showed enhanced sphere formation and CD133 expression in colon cancer cell lines made resistant to 5-fluorouracil, along with increased OXPHOS activity and high ROS, reduced glucose uptake and PPP activity, and a small effect of metformin on proliferation. Here, PROM1 is linked to malignant colon neoplasm.