In line with PGC1α-independent upregulation of mitochondria, we have reported that in a tissue microarray of ovarian cancer, the high-grade serous carcinomas expressed high levels of PGC1α, whereas in the clear-cell subtype PGC1α and TFAM were undetectable, along with high levels of the mitochondrial marker VDAC [73]. This evidence concerns the gene PPARGC1A and ovarian cancer.