NOTCH3 and neoplasm: On the other hand, the expression levels of SUSD2 (Figure 10A), a Notch 3-regulating protein that also suppresses metastasis in high-grade serous ovarian carcinoma [146], and of STAT6, playing a major role in regulation of IL-4 synthesis, reducing colon inflammation during tumorigenesis but facilitating tumor formation [147], increased (150- and 12-fold, respectively).