It has been proposed that glioma CSCs express differentiation markers similar to those in normal glia and neurons [131], such as of oligodendrocytes (ASCL1, OLIG2 and DLL3), astrocytes (GFAP), neurons (β-tubulin III, SYT1 and SLC12A5), and markers of inflamed astroglial cells (SERPINE1, TGFB1 and RELB) [132]. This evidence concerns the gene DLL3 and central nervous system cancer.