Recently, we showed in cultured cells of GBM, lung cancer and triple negative breast cancer that although VDAC1 silencing occurred within a day, the cells underwent reprograming with respect to rewiring metabolism, elimination of CSCs, alteration of transcription factor (TF) expression and differentiation, were developed with time and maximal changes were observed after 3 weeks of silencing VDAC1 expression [21]. The gene discussed is VDAC1; the disease is glioblastoma.