Differentiation of nasopharyngeal carcinoma cells was induced via inhibiting an epigenetic mechanism by which EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) represses IKKα (inhibitor of nuclear factor kappa-B kinase subunit beta) expression and impairs tumor cell differentiation [135]. The gene discussed is IKBKB; the disease is nasopharyngeal carcinoma.