RRAD and hepatocellular carcinoma: Indeed, (Figure 10, Table S5), the expression levels of RRAD (Ras-related associated diabetes), which functions in hepatocellular carcinoma as a metastasis suppressor [51], and of STAT6 (signal transducer and activator of transcription 6), which activates gene transcription in response to cytokines [52], increased 2-3 fold after a short-term treatment with si-hVDAC1 but over 12-fold following long-term treatment with si-hVDAC1 (Figure 6, Table S5).