PLXNB2 (plexin B2) that functions as an activator of GTPase Rho [56] tumor cell proliferation and invasion [57] and mediates angiogenesis-supporting tumor growth [58] and tumor metastasis [55], and LANCL2 (lanthionine synthetase C-like protein 2), a signaling pathway protein that is expressed in the plasma and nuclear membranes of immune cells and neurons, as well as in the gastrointestinal tract, testis and pancreas [59]. The gene discussed is RHO; the disease is neoplasm.