The experimental protocol for testing the effect of short- and long-term treatment with non-targeting si-RNA (si-NT) or si-hVDAC1 is presented in Figure 1A. Silencing VDAC1 expression in U-87MG cell-derived tumors by si-hVDAC1 led to marked decreases in tumor growth following short- or long-term treatment with the si-RNA (Figure 1B,C). The gene discussed is VDAC1; the disease is neoplasm.