Thus, we propose the complex study where classical AKI markers i.e., creatinine, uric acid, urea, novel uremic toxins i.e. TMAO, ADMA, SDMA were determined in serum and novel urinary markers of AKI i.e., NGAL, KIM-1 and Cyst-C were determined in urine of volunteers after 10- and 100-km runs. Here, LCN2 is linked to acute kidney injury.