Thus, we propose the complex study where classical AKI markers i.e., creatinine, uric acid, urea, novel uremic toxins i.e. TMAO, ADMA, SDMA were determined in serum and novel urinary markers of AKI i.e., NGAL, KIM-1 and Cyst-C were determined in urine of volunteers after 10- and 100-km runs. The gene discussed is HAVCR1; the disease is acute kidney injury.