NLRP3 and obesity due to melanocortin 4 receptor deficiency: By using Nlrp3−/−, Nlrc4−/−, Casp1/11−/−, and WT obesity-prone C57BL/6 mice, another study concluded that the NLRC4 inflammasome, associated often with obesity, has a more important role in BC progression than the NLRP3 inflammasome.