In a retrospective analysis of AML patients who underwent autologous HSCT at University of California, MRD assessed by RQ-PCR for a multigene panel in cryopreserved autograft appeared to be highly predictive for relapse in patients with known chromosomal abnormalities or mutations, including WT1, mutated NPM1, t(8;21), inv(16), and t(15;17) [77]. The gene discussed is NPM1; the disease is acute myeloid leukemia.