Moreover, focusing on LSC frequency in adults with AML, Terwijn M. et al. demonstrated that higher percentages of neoplastic CD34+CD38− cells at diagnosis as well as in CR post various courses of therapy strongly correlates with shorter patient survival, while the neoplastic parts of the CD34+CD38+ and CD34− putative stem cell compartments had no prognostic impact [42]. The gene discussed is CD38; the disease is acute myeloid leukemia.