Thus, expression and regulation throughout lactation of miRNA genes that are putative targets of leptin (miR-146b, miR-27a, miR-27b, miR-17, miR-30a), adiponectin (miR-181a, miR-27a, miR-27b), and their receptors (miR-let 7a, miR-let7b, miR-let7c, miR-222, miR-30a) or related to adipogenesis and obesity (miR-103, miR-17) were characterized in overweight/obese lactating mothers in comparison with normal-weight mothers. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.