On the one hand, down-regulated expressed TFs could down-regulate some miRNA expression to further up-regulate tumor suppressor gene expression, whilst the down-regulated miRNAs could also up-regulate TF expression to further up-regulate the expression of tumor suppressor miRNA to down-regulate the expression of some oncogenes to improve prognosis for ccRCC. Here, TF is linked to nonpapillary renal cell carcinoma.