SOCS2 and Familial prostate cancer: Remarkably, some previous reports showed that the transcription factor GATA2 could activate the expression of miR-194 to promote this distant metastasis of prostate cancer by inhibiting SOCS2 [72], and the transcription factor KLF5 could also promote the expression of miR-145, miR-124, and miR-183 by binding to their promoter involved in the progression of invasive pituitary adenoma [73], as well as the transcription factor TFAP2C could promote lung tumorigenesis and aggressiveness through it activating miR-183 and miR-33a-mediated cell cycle regulation [74].