In addition, the eleven-gene signature (hsa-miR-365b-3p, hsa-miR-223-3p, hsa-miR-1269a, hsa-miR-144-5p, hsa-miR-183-5p, hsa-miR-335-3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) can sever as an effective prognostic predictor to significantly improve the overall survival of ccRCC patients. The gene discussed is TFAP2A; the disease is nonpapillary renal cell carcinoma.