Herein, we identified nine potential prognostic TFs (TFAP2A, KLF5, IRF1, RUNX1, RARA, GATA3, IKZF1, POU2F2, and FOXM1) that could act as prognostic factors for ccRCC patients. The gene discussed is POU2F2; the disease is nonpapillary renal cell carcinoma.