Although studies on the function roles of the other three miRNAs in ccRCC are still less reported to date, some other studies have revealed that hsa-miR-1269a could function as an onco-miRNA in NSCLC via down-regulating its target SOX6 [62], as well as that miR-1269a could promote colorectal cancer (CRC) metastasis by targeting Smad7 and HOXD10 [63]. The gene discussed is SMAD7; the disease is colorectal carcinoma.