IGFBP-7 knockout can activate ERK1/2 signaling pathway, reduce creatinine, urea nitrogen, albumin, and cell apoptosis in mice urine, and effectively reduce the severity of renal injury, indicating that IGFBP-7 regulates AKI induced by sepsis through ERK1/2 signaling [46]. The gene discussed is MAPK3; the disease is acute kidney injury.