IGF1R and rheumatoid arthritis: In addition, when RA-FLSs were transfected with miR-129-5p mimics, the relative expression of p-src/c-src and p-ERK/ERK were significantly increased, while after further transfecting with pcDNA3.1-IGF-1R, the relative expression of p-src/c-src and p-ERK/ERK were significantly decreased (Figure 6B,C).