We previously demonstrated that CCR5 blockade or mutation is associated with decreased hepatic fibrosis among patients with HIV infection, including those with HCV coinfection.[14] In the current study, we explored the effects of CCR5 inhibition or knockdown on HCV replication in tissue culture-based model systems to clarify the observed associations between CCR5 and HCV replication. This evidence concerns the gene CCR5 and Hepatic fibrosis.