Coding polymorphisms in the consensus Chr 17 area included those linked to cancer (Fndc1, Tiam2, Zdhhc14 Has1) [48,52,56,64], growth and development (Igf2r, Afdn, Tiam2, T2) [49,57,63], immunology [53] or diabetes itself via the energetic electron transfer chain (Tiam2, Pde10A) [50,51] or basal thermal metabolism [61]. This evidence concerns the gene AFDN and diabetes mellitus.