By comparing the liver and spleen pathology with other pathological situations, especially involving the liver sinusoids, we found some similarities of the phenotype observed in Mfsd1 KO mice (and Glmp KO mice) with ‘sinusoidal obstruction syndrome’ (SOS), a pathology observed in humans and mouse models treated with oxaliplatin (an adjuvant or neoadjuvant for chemotherapy for colorectal carcinoma) or patients taking pyrrolizidine alkaloid-containing herbal remedies (DeLeve et al., 2002; Fan and Crawford, 2014). Here, MFSD1 is linked to hepatic veno-occlusive disease.