Indeed, numerous case–control studies [15–28] have investigated whether polymorphisms at position -137 (rs187238) or -607 (rs1946518) within the IL-18 promoter influence the risk of CAD, but the results were inconclusive and contradictory, prompting us to perform a comprehensive meta-analysis of all available evidence on these potential associations. This evidence concerns the gene IL18 and coronary artery disorder.