A similar explanation may underlie the apparent lack of efficacy of Sarm1 deletion in a mutant SOD1 mouse model of ALS, which demonstrates rapid disease onset and progression [57], and in our previous study in Drosophila in which even clonal TDP-43Q331K overexpression causes early and aggressive neurodegeneration [69]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.