CXCR4 antagonists potentiate ICI effect in HCC xenograft [9], in murine intraperitoneal papillary epithelial ovarian cancer [13] and in murine colorectal cancer where NOX-A12, the CXCL12 antagonist L-RNA-aptamer, enhanced CD8 and NK infiltration [14]. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.