The levels of TIPE2 mRNA were significantly upregulated in patients with CHB and LC compared with the levels in healthy controls (CHB: 2.1[1.24, 2.91] vs. 1.00[0.94, 1.33], P < 0.01; LC: 1.74[1.34, 3.05] vs. 1.00[0.94, 1.33], P < 0.01), whereas there were no significant differences between CHB patients and LC patients. Here, TIPE2 is linked to laryngotracheoesophageal cleft.