Furthermore, TIPE2 mRNA had an AUC of 0.957 (95% CI: 0.918–0.981, P < 0.001), and the optimal cutoff was 0.78 with a sensitivity of 97.56%, a specificity of 88.16%, a PPV of 69% and an NPV of 99.3% in discriminating HBV-associated HCC from CHB and LC patients. The gene discussed is TIPE2; the disease is hepatocellular carcinoma.