Furthermore, our findings established that both lncRNA SNHG14 silencing or miR-34c-3p over-expression are capable of reducing the levels of pro-inflammatory cytokines (IL-18, IL-1, TNF-α and IL-6), and thereby alleviate pulmonary edema in ALI models via down-regulation of WISP1. Here, CCN4 is linked to acute respiratory distress syndrome.