INSR and type 2 diabetes mellitus: Unfortunately, the biochemical mechanisms by which magnesium and potassium deficiency induces or worsens T2DM in GS-individuals are not well understood, but it is thought that these electrolytic alterations may induce altered cellular glucose transport, defective post receptor insulin signaling, impaired secretion of biologically active insulin as well as altered insulin-insulin receptor interactions [51, 52].