Furthermore, the inactivation of the Na-Cl co-transporter (SLC12A3) gene is known for being responsible for Gitelman Syndrome (GS), an autosomal recessive renal tubular disorder characterized by hypokalaemia, marked metabolic alkalosis, hypomagnesemia, hypocalciuria, as well as renal potassium and magnesium wasting [30, 31]. The gene discussed is SLC12A3; the disease is Gitelman syndrome.