This preferential downregulation and increased degradation of myosin and sparing of α‐Actin is not unique to sepsis; it has been observed in response to aging, immobilization, cancer cachexia, and in patients with myopathies brought on by critical illness (D'Antona et al., 2003; Acharyya et al., 2004; Friedrich et al., 2015). The gene discussed is MYH14; the disease is myopathy.