In addition, HLA‐B*39 polymorphism associates with a lower age of type 1 diabetes diagnosis, and the HLA‐B*3906 subtype is linked to a lower age of diagnosis by an average of 1·7–3·7 years in several independent studies 17, 20, 21, 22, 23, 24. This evidence concerns the gene HLA-B and type 1 diabetes mellitus.