For example, in subjects with type 1 diabetes, we observe a larger proportion of memory T cell subsets in the PPI5–12‐specific CD8+ T cell population compared to the polyclonal CD8+ T cell population, illustrated by a red polygon (representing PPI‐specific T cells) that is more expanded along the arcs of the web compared to the blue polygon (representing polyclonal CD8+ T cells) (Fig. 1e). This evidence concerns the gene CD8A and type 1 diabetes mellitus.