studied the relationship between SPAG6 and otitis media, and they have proved that SPAG6 regulates cilia/basal body polarity through the PCP-dependent mechanisms that not only regulate cilium location or orientation, but also regulate basal body docking to the apical surface during ciliogenesis in the middle ear and Eustachian tubes.40, 41 Li et al.’s39 study showed that the orientation of the ciliary basal feet was random in the middle ear epithelial cells of SPAG6-deficient mice. Here, SPAG6 is linked to otitis media.