ITGAV and metastatic malignant neoplasm: Integrins are the major cell-adhesive receptor; are key components of signaling molecules, mechanical transducers, and cellular migration mechanisms; and are involved in many aspects ranging from primary tumor to metastatic cancer progression (Hamidi & Ivaska, 2018) Integrin-alpha-5 (ITGA5) and integrin-alpha-V (ITGAV) are members of the integrin receptor gene family, closely related to the regulation of cancer growth and metastasis (Chernaya et al., 2018; Morandi et al., 2016).