DNMT1 and obesity due to melanocortin 4 receptor deficiency: Indeed, some success has been reported in this regard, with studies showing that the manipulation of the epigenetic machinery, such as DNA methyltransferase‐1 (DNMT1) and DNA methyltransferase‐3a (DNMT3a), could be a useful strategy in treating obesity (Bruggeman, Garretson, Wu, Shi, & Xue, 2018; Kohno et al., 2014).