VEGFA and medical procedure: GALILEO (General Assessment Limiting Infiltration of Exudates in Central Retinal Vein Occlusion with VEGF Trap-Eye) and COPERNICUS (Vascular Endothelial Growth Factor [VEGF] Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion) are multicenter randomized clinical studies that evaluated the intravitreal aflibercept effects in patients with CRVO-ME.[43,44,45,46,47,48]