Although the “treat-and-extend" regimen is frequently applied in anti-VEGF treatment in age-related macular degeneration, this protocol has also been recently used in ME due to RVOs using aflibercept with good outomes.[51] All trials showed that repeated anti-VEGF injection was associated with significant improvement in the functional outcomes at six months compared to the placebo. Here, VEGFA is linked to age-related macular degeneration.