In the current study, pathogenic/likely pathogenic MLH1/MSH2 variants were identified in 34.5% (10/29) of Pakistani HNPCC/suspected-HNPCC patients, which is in agreement with other Asian studies from Korea (54/188; 28.7%), China (7/23; 30.4%), and Singapore (17/59; 28.8%) [39–41], Poland (78/226; 34.5%) [32], US (26/71; 36.6%) [42], and Brazil (44/116; 38%) [5]. This evidence concerns the gene MSH2 and hereditary nonpolyposis colon cancer.