The index CRC patients with pathogenic/likely pathogenic MLH1/MSH2 variants (n = 11) and without pathogenic variants (n = 199) had a same median age of diagnosis, 43 years (range 32–61) and 43 years (range 14–77) of age, respectively (P = 0.74, Wilcoxon rank-sum test). The gene discussed is MSH2; the disease is colorectal carcinoma.