The decreased Caspase 3 activation in paclitaxel-treated MCF-7/CapG xenograft tumors, compared with that in MCF-7 xenografts (Figure 7E), further supported an anti-apoptotic role of CapG in paclitaxel-treated breast cancers, likely owing to increased PI3K/Akt activation. Here, PIK3CA is linked to breast carcinoma.