Furthermore, it has been revealed that PI3K/Akt/XIAP axis is implicated in the apoptosis resistance of HL-60 cells in the condition of co-culturing with BMSCs through direct cell contact, and the inhibition of PI3K/Akt/XIAP axis may provide a promising therapeutic strategy for the treatment of acute myeloid leukemia [21]. The gene discussed is XIAP; the disease is acute myeloid leukemia.