NOTCH2 and diffuse large B-cell lymphoma: The genetic composition of the obscure UC subgroup has remained largely unknown, however, a recent study found that concomitant NOTCH2 mutations and BCL6 translocations characterized the UC subgroup and were associated with a favorable survival outcome.37 These findings suggest that further subgrouping of ABC, GCB and UC, by including genetic data might be necessary in order to correctly risk stratify patients with DLBCL.