NRAS and melanoma: In a panel of NRAS-mutated melanoma cell lines, XL888 caused degradation of IGF-1Rβ, PDGFR-β, c-MET and VEGFR1 (vascular endothelial growth factor receptor (1), although it surprisingly increased VEGFR2 (vascular endothelial growth factor receptor (2) level in one cell line [140].