ERBB2 and breast carcinoma: These 111In-trastuzumab-AuNPs were bound by HER2-positive SK-BR-3 or MDA-MB-361 human breast cancer cells and were internalised to a peri-nuclear location, likely mediated by a nuclear translocation sequence (NLS) in HER2 (Chen et al. 2005) (Fig. 9b).