ICAM1 and Alzheimer disease: In addition to lower plasma level of KYNA, increased levels of KYN and KYNA were detected in glioblastoma cells and in the CSF of patients with Alzheimer’s disease where KYNA amount correlated with the expression of P-tau and the soluble intercellular adhesion molecule-1 which are biomarkers of inflammation (Opitz et al. 2011).