TARDBP and Alzheimer disease: However, in both PCA and lvPPA a significant minority of cases showed other underlying pathologies than AD, e.g. Lewy bodies, transactive response DNA binding protein of about 43 kDa (TAR DNA-binding protein 43, TDP-43) proteinopathies, “pure” tauopathy or cerebrovascular disease (Crutch et al. 2012; Harris and Jones 2014) (Table 1).