First-generation tau PET radiotracers – [18F]AV-1451, [11C]PBB3, [18F]THK5351 (Fig. 8) – showed favourable kinetics and high affinity to the 3R/4R tau isoform combination which is typical in AD (Villemagne et al. 2015; Lois et al. 2018; Villemagne 2018). Here, MAPT is linked to Alzheimer disease.