ACHE and Alzheimer disease: Thus, using abovementioned radioligands, reduced activities of VChAT and AChE were demonstrated in various neurodegenerative diseases like AD, PD and DLB (Kuhl et al. 1996; Kuhl et al. 1999; Roy et al. 2016; Aghourian et al. 2017; Bohnen et al. 2019).