Therefore, several approaches have been used to treat tumors by targeting FAP: immunoconjugates (Ostermann et al. 2008), CAR T cells (Wang et al. 2014; Lo et al. 2015), tumor immunotherapy (Lee et al. 2005), vaccines (Loeffler et al. 2006), peptide drug complexes (Brennen et al. 2012a, 2012b; Chen et al. 2017; LeBeau et al. 2009; Wang et al. 2017), FAP inhibitors (Teichgräber et al. 2015) and antibodies (Hofheinz et al. 2003; Scott et al. 2003; Welt et al. 1994; Wüst et al. 2001). This evidence concerns the gene FAP and neoplasm.