Pulmonary lymphoepithelioma-like carcinoma and EBV+ nasopharyngeal carcinoma had a comparable TP53 mutation frequency (25.9 vs. 12.5%, P = 0.21) but it had a significantly higher TP53 mutation frequency than EBV+ gastric tumors (25.9 vs. 3.3%, P = 0.021). This evidence concerns the gene TP53 and nasopharyngeal carcinoma.