Furthermore, our analysis revealed that pulmonary lymphoepithelioma-like carcinoma had a significantly lower mutation frequencies in TP53 (54.1 vs. 25.9%, P = 0.005), KRAS (32.4 vs. 3.7%, P < 0.001), and LRP1B (35.0 vs. 7.4%, P = 0.003) than lung adenocarcinoma. Here, TP53 is linked to lung adenocarcinoma.